Profile of David M. Sabatini.

نویسنده

Jennifer Viegas

چکیده

As a young doctoral candidate at the Johns Hopkins University School of Medicine, David M. Sabatini was allowed to choose his own research project for his thesis. He chose to investigate the molecular mechanism of rapamycin, a compound with antifungal, antitumor, and immunosuppressant properties. The decision was pivotal, because Sabatini went on to discover the mechanistic target of rapamycin (mTOR) protein and signaling pathway, which serves as a central regulator of cell metabolism, growth, and proliferation. Sabatini, a professor of biology at the Massachusetts Institute of Technology (MIT) and a member of the Whitehead Institute, and his team subsequently identified two distinct multiprotein complexes that contain mTOR, as well as associated proteins involved in nutrient sensing. Because the mTOR pathway is activated during numerous cellular processes and deregulated in aging and diseases, such as cancer, epilepsy, and diabetes, his research has attracted broad interest. In recognition of his research achievements, Sabatini received the National Academy of Sciences (NAS) Award in Molecular Biology in 2014, and was elected to the NAS in 2016. His Inaugural Article (1) describes the development of the mTOR and nutrient sensing fields from their inception to the present.

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منابع مشابه

Cell biology. The TASCC of secretion.

Roberto Zoncu1,2,3 and David M. Sabatini1,2,3,4 David M. Sabatini: [email protected] 1Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA 2Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 3The David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA 4Howard Hugh...

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mTOR signaling at a glance.

glance Mathieu Laplante1,2 and David M. Sabatini1,2,3,* 1Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA 2Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 3Koch Center for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA *Author for corresponde...

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Award Number : W 81 XWH - 07 - 1 - 0448 TITLE : Structural and Mechanistic Analyses of TSC 1 / 2 and Rheb 1 / 2 - Mediated Regulation of the mTORC Pathway

Award Number: W81XWH-07-1-0448 TITLE: Structural and Mechanistic Analyses of TSC1/2 and Rheb 1/2Mediated Regulation of the mTORC Pathway PRINCIPAL INVESTIGATOR: PI: David M. Sabatini, M.D./Ph.D. CONTRACTING ORGANIZATION: Whitehead Institute for Biomedical Research Cambridge, MA 02142-1493 REPORT DATE: July 2009 TYPE OF REPORT: Annual Report PREPARED FOR: U.S. Army Medical Research and Materiel ...

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